Group-combined P-values with applications to genetic association studies

Motivation: In large-scale genetic association studies with tens of hundreds of single nucleotide polymorphisms (SNPs) genotyped, the traditional statistical framework of logistic regression using maximum likelihood estimator (MLE) to infer the odds ratios of SNPs may not work appropriately. This is...

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Bibliographic Details
Published in:Bioinformatics
Main Authors: Hu, Xiaonan, Zhang, Wei, Zhang, Sanguo, Ma, Shuangge, Li, Qizhai
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Original Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018368/
https://ncbi.nlm.nih.gov/pubmed/27259542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw314
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