Characterisation of the epigenetic changes during human gonadal primordial germ cells reprogramming

Epigenetic reprogramming is a central component of the mammalian germline development. Genome-wide DNA demethylation observed in primordial germ cells (PGCs) is a prerequisite for erasure of epigenetic memory, preventing the transmission of epimutations to the next generation. Apart from DNA demethy...

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Bibliographic Details
Published in:Stem Cells
Main Authors: Eguizabal, C, Herrera, L, de Oñate, L, Montserrat, N, Hajkova, P, Izpisua-Belmonte, JC
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018215/
https://ncbi.nlm.nih.gov/pubmed/27300161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2422
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