Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation

Human metapneumovirus (hMPV) is a paramyxovirus that is a common cause of bronchiolitis and pneumonia in children less than five years of age. The hMPV fusion (F) glycoprotein is the primary target of neutralizing antibodies and is thus a critical vaccine antigen. To facilitate structure-based vacci...

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Publicado en:PLoS Pathog
Autores principales: Más, Vicente, Rodriguez, Laura, Olmedillas, Eduardo, Cano, Olga, Palomo, Concepción, Terrón, María C., Luque, Daniel, Melero, José A., McLellan, Jason S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017722/
https://ncbi.nlm.nih.gov/pubmed/27611367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005859
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