Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction

TRAF3IP2 (TRAF3 interacting protein 2; previously known as CIKS or Act1) is a key intermediate in the normal inflammatory response and the pathogenesis of various autoimmune and inflammatory diseases. Induction of TRAF3IP2 activates IκB kinase (IKK)/NF-κB, JNK/AP-1, and c/EBPβ and stimulates the exp...

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Udgivet i:J Biol Chem
Main Authors: Yariswamy, Manjunath, Yoshida, Tadashi, Valente, Anthony J., Kandikattu, Hemanth Kumar, Sakamuri, Siva S. V. P., Siddesha, Jalahalli M., Sukhanov, Sergiy, Saifudeen, Zubaida, Ma, Lixin, Siebenlist, Ulrich, Gardner, Jason D., Chandrasekar, Bysani
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016681/
https://ncbi.nlm.nih.gov/pubmed/27466370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.724138
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