TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation

TRAF3IP2 is a cytoplasmic adapter protein and an upstream regulator of IKK/NF-κB and JNK/AP-1. Here we demonstrate for the first time that the proinflammatory cytokine interleukin (IL)-18 induces TRAF3IP2 expression in primary cardiac fibroblasts (CF) in a Nox4/hydrogen peroxide-dependent manner. Si...

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Detalhes bibliográficos
Main Authors: Valente, Anthony J., Sakamuri, Siva S.V.P., Siddesha, Jalahalli M., Yoshida, Tadashi, Gardner, Jason D., Prabhu, Ramesh, Siebenlist, Ulrich, Chandrasekar, Bysani
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793247/
https://ncbi.nlm.nih.gov/pubmed/23872479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.07.013
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