A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However, recent evidence suggests that the accepted view of APP proteolysis by the canonical α-, β-, and γ-secretases is simplistic...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Andrew, Robert J., Kellett, Katherine A. B., Thinakaran, Gopal, Hooper, Nigel M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016663/
https://ncbi.nlm.nih.gov/pubmed/27474742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R116.746032
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