Cryopreserved MSCs are susceptible to T-cell mediated apoptosis which is partly rescued by IFNγ licensing

We have previously demonstrated that cryopreservation and thawing lead to altered MSC functionalities. Here, we further analyzed MSC's fitness post freeze-thaw. We have observed that thawed MSC can suppress T-cell proliferation when separated from them by transwell membrane and the effect is lo...

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Bibliografiske detaljer
Udgivet i:	Stem Cells
Main Authors:	Chinnadurai, Raghavan, Copland, Ian B, Garcia, Marco A, Petersen, Christopher T, Lewis, Christopher N, Waller, Edmund K, Kirk, Allan D, Galipeau, Jacques
Format:	Artigo
Sprog:	Inglês
Udgivet:	2016
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5016228/ https://ncbi.nlm.nih.gov/pubmed/27299362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2415
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Cryopreserved MSCs are susceptible to T-cell mediated apoptosis which is partly rescued by IFNγ licensing

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