Immune dysfunctionality of replicative senescent mesenchymal stromal cells is corrected by IFNγ priming

Industrial-scale expansion of mesenchymal stromal cells (MSCs) is often used in clinical trials, and the effect of replicative senescence on MSC functionality is of mechanistic interest. Senescent MSCs exhibit cell-cycle arrest, cellular hypertrophy, and express the senescent marker β-galactosidase....

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Chinnadurai, Raghavan, Rajan, Devi, Ng, Spencer, McCullough, Kenneth, Arafat, Dalia, Waller, Edmund K., Anderson, Larry J., Gibson, Greg, Galipeau, Jacques
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507374/
https://ncbi.nlm.nih.gov/pubmed/28713871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017006205
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