Mesenchymal Stromal Cells Derived From Crohn's Patients Deploy Indoleamine 2,3-dioxygenase-mediated Immune Suppression, Independent of Autophagy

Autologous bone marrow-derived mesenchymal stromal cells (MSCs) for adoptive cell therapy of luminal Crohn's disease (CD) are being tested in clinical trials. However, CD is associated with dysregulation of autophagy and its effect on MSC's immunobiology is unknown. Here, we demonstrate no...

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Publicado en:Mol Ther
Autores principales: Chinnadurai, Raghavan, Copland, Ian B, Ng, Spencer, Garcia, Marco, Prasad, Mahadev, Arafat, Dalia, Gibson, Greg, Kugathasan, Subra, Galipeau, Jacques
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817795/
https://ncbi.nlm.nih.gov/pubmed/25899824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.67
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