Mesenchymal Stromal Cells Derived From Crohn's Patients Deploy Indoleamine 2,3-dioxygenase-mediated Immune Suppression, Independent of Autophagy

Autologous bone marrow-derived mesenchymal stromal cells (MSCs) for adoptive cell therapy of luminal Crohn's disease (CD) are being tested in clinical trials. However, CD is associated with dysregulation of autophagy and its effect on MSC's immunobiology is unknown. Here, we demonstrate no...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Ther
Egile Nagusiak: Chinnadurai, Raghavan, Copland, Ian B, Ng, Spencer, Garcia, Marco, Prasad, Mahadev, Arafat, Dalia, Gibson, Greg, Kugathasan, Subra, Galipeau, Jacques
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817795/
https://ncbi.nlm.nih.gov/pubmed/25899824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.67
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