Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma

The protein kinase casein kinase 2 (CK2) is a pleiotropic and constitutively active kinase that plays crucial roles in cellular proliferation and survival. Overexpression of CK2, particularly the α catalytic subunit (CK2α, CSNK2A1), has been implicated in a wide variety of cancers and is associated...

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Udgivet i:J Biol Chem
Main Authors: Zhou, Bingying, Ritt, Daniel A., Morrison, Deborah K., Der, Channing J., Cox, Adrienne D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016172/
https://ncbi.nlm.nih.gov/pubmed/27226552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.712885
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