Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-induced Phospho-regulatory Circuit

Ras pathway signaling plays a critical role in cell growth control and is often upregulated in human cancer. The Raf kinases selectively interact with GTP-bound Ras and are important effectors of Ras signaling, functioning as the initiating kinases in the ERK cascade. Here, we identify a route for t...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Ritt, Daniel A., Blanco, Maria Abreu, Bindu, Lakshman, Durrant, David E., Zhou, Ming, Specht, Suzanne I., Stephen, Andrew G., Holderfield, Matthew, Morrison, Deborah K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135640/
https://ncbi.nlm.nih.gov/pubmed/27889448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.10.029
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