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Design and Characterization of Erwinia Chrysanthemi l-Asparaginase Variants with Diminished l-Glutaminase Activity

Current FDA-approved l-asparaginases also possess significant l-glutaminase activity, which correlates with many of the toxic side effects of these drugs. Therefore, l-asparaginases with reduced l-glutaminase activity are predicted to be safer. We exploited our recently described structures of the E...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Nguyen, Hien Anh, Su, Ying, Lavie, Arnon
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016162/
https://ncbi.nlm.nih.gov/pubmed/27354283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.728485
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