The Central Polybasic Region of the Soluble SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Vam7 Affects Binding to Phosphatidylinositol 3-Phosphate by the PX (Phox Homology) Domain

The yeast vacuole requires four SNAREs to trigger membrane fusion including the soluble Qc-SNARE Vam7. The N-terminal PX domain of Vam7 binds to the lipid phosphatidylinositol 3-phosphate (PI3P) and the tethering complex HOPS (homotypic fusion and vacuole protein sorting complex), whereas the C-term...

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Vydáno v:J Biol Chem
Hlavní autoři: Miner, Gregory E., Starr, Matthew L., Hurst, Logan R., Sparks, Robert P., Padolina, Mark, Fratti, Rutilio A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016161/
https://ncbi.nlm.nih.gov/pubmed/27365394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.725366
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