The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization

We previously reported that the vesicular monoamine transporter 2 (VMAT2) is physically and functionally coupled with Hsc70 as well as with the dopamine synthesis enzymes tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase, providing a novel mechanism for dopamine homeostasis regulation....

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Parra, Leonardo A., Baust, Tracy B., Smith, Amanda D., Jaumotte, Juliann D., Zigmond, Michael J., Torres, Soledad, Leak, Rehana K., Pino, Jose A., Torres, Gonzalo E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016148/
https://ncbi.nlm.nih.gov/pubmed/27365397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.728782
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