Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation

Slow deactivation of Kv11.1 channels is critical for its function in the heart. The S4-S5 linker, which joins the voltage sensor and pore domains, plays a critical role in this slow deactivation gating. Here, we use NMR spectroscopy to identify the membrane-bound surface of the S4S5 linker, and we s...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ng, Chai-Ann, Gravel, Andrée E., Perry, Matthew D., Arnold, Alexandre A., Marcotte, Isabelle, Vandenberg, Jamie I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016128/
https://ncbi.nlm.nih.gov/pubmed/27317659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729392
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