PtdIns(3,4,5)P(3)-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling

PtdIns(3,4,5)P(3)-dependent Rac exchanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed in a significant proportion of human breast cancers that integrates signals from upstream ErbB2/3 and CXCR4 membrane surface receptors. However, the PREX1 domains that facilitate its o...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Liu, Heng-Jia, Ooms, Lisa M., Srijakotre, Nuthasuda, Man, Joey, Vieusseux, Jessica, Waters, JoAnne E., Feng, Yue, Bailey, Charles G., Rasko, John E. J., Price, John T., Mitchell, Christina A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016125/
https://ncbi.nlm.nih.gov/pubmed/27358402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.743401
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