Identification of Plant-derived Alkaloids with Therapeutic Potential for Myotonic Dystrophy Type I

Myotonic dystrophy type I (DM1) is a disabling neuromuscular disease with no causal treatment available. This disease is caused by expanded CTG trinucleotide repeats in the 3′ UTR of the dystrophia myotonica protein kinase gene. On the RNA level, expanded (CUG)(n) repeats form hairpin structures tha...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Herrendorff, Ruben, Faleschini, Maria Teresa, Stiefvater, Adeline, Erne, Beat, Wiktorowicz, Tatiana, Kern, Frances, Hamburger, Matthias, Potterat, Olivier, Kinter, Jochen, Sinnreich, Michael
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016119/
https://ncbi.nlm.nih.gov/pubmed/27298317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.710616
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