Identification of Plant-derived Alkaloids with Therapeutic Potential for Myotonic Dystrophy Type I

Myotonic dystrophy type I (DM1) is a disabling neuromuscular disease with no causal treatment available. This disease is caused by expanded CTG trinucleotide repeats in the 3′ UTR of the dystrophia myotonica protein kinase gene. On the RNA level, expanded (CUG)(n) repeats form hairpin structures tha...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Herrendorff, Ruben, Faleschini, Maria Teresa, Stiefvater, Adeline, Erne, Beat, Wiktorowicz, Tatiana, Kern, Frances, Hamburger, Matthias, Potterat, Olivier, Kinter, Jochen, Sinnreich, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016119/
https://ncbi.nlm.nih.gov/pubmed/27298317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.710616
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