Identification of Plant-derived Alkaloids with Therapeutic Potential for Myotonic Dystrophy Type I

Myotonic dystrophy type I (DM1) is a disabling neuromuscular disease with no causal treatment available. This disease is caused by expanded CTG trinucleotide repeats in the 3′ UTR of the dystrophia myotonica protein kinase gene. On the RNA level, expanded (CUG)(n) repeats form hairpin structures tha...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Herrendorff, Ruben, Faleschini, Maria Teresa, Stiefvater, Adeline, Erne, Beat, Wiktorowicz, Tatiana, Kern, Frances, Hamburger, Matthias, Potterat, Olivier, Kinter, Jochen, Sinnreich, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016119/
https://ncbi.nlm.nih.gov/pubmed/27298317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.710616
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