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Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold

Human leukocyte cell-derived chemotaxin 2 (LECT2), which is predominantly expressed in the liver, is a multifunctional protein. LECT2 is becoming a potential therapeutic target for several diseases of worldwide concern such as rheumatoid arthritis, hepatocellular carcinoma, and obesity. Here, we pre...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Zheng, Hai, Miyakawa, Takuya, Sawano, Yoriko, Asano, Atsuko, Okumura, Akinori, Yamagoe, Satoshi, Tanokura, Masaru
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016117/
https://ncbi.nlm.nih.gov/pubmed/27334921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.720375
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