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Absolute Side-chain Structure at Position 13 Is Required for the Inhibitory Activity of Bromein

Bromelain isoinhibitor (bromein), a cysteine proteinase inhibitor from pineapple stem, has a unique double-chain structure. The bromein precursor protein includes three homologous inhibitor domains, each containing an interchain peptide between the light and heavy chains. The interchain peptide in t...

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Detalhes bibliográficos
Main Authors: Sawano, Yoriko, Hatano, Ken-ichi, Miyakawa, Takuya, Tanokura, Masaru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662299/
https://ncbi.nlm.nih.gov/pubmed/18948264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806748200
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