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Loss of bound zinc facilitates amyloid fibril formation of leukocyte-cell-derived chemotaxin 2 (LECT2)

Aggregation of the circulating protein leukocyte-cell-derived chemotaxin 2 (LECT2) causes amyloidosis of LECT2 (ALECT2), one of the most prevalent forms of systemic amyloidosis affecting the kidney and liver. The I40V mutation is thought to be necessary but not sufficient for ALECT2, with a second,...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ha, Jeung-Hoi, Tu, Ho-Chou, Wilkens, Stephan, Loh, Stewart N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039541/
https://ncbi.nlm.nih.gov/pubmed/33617884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100446
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