Chromosome 17p Homodisomy Is Associated With Better Outcome in 1p19q Non-Codeleted and IDH-Mutated Gliomas

BACKGROUND. The 1p19q non-codeleted gliomas with IDH mutation, defined as “molecular astrocytomas,” display frequent TP53 mutations and have an intermediate prognosis. We investigated the prognostic impact of copy number-neutral loss of heterozygosity (CNLOH) in 17p in this population. METHODS. We a...

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Vydáno v:Oncologist
Hlavní autoři: Labussière, Marianne, Rahimian, Amithys, Giry, Marine, Boisselier, Blandine, Schmitt, Yohann, Polivka, Marc, Mokhtari, Karima, Delattre, Jean-Yves, Idbaih, Ahmed, Labreche, Karim, Alentorn, Agusti, Sanson, Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2016
Témata:
Neuro-Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016064/
https://ncbi.nlm.nih.gov/pubmed/27401888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2016-0003
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