Therapeutic TNF Inhibitors can Differentially Stabilize Trimeric TNF by Inhibiting Monomer Exchange

Tumor necrosis factor (TNF) is a homotrimeric cytokine that is a key mediator of inflammation. It is unstable at physiological concentrations and slowly converts into an inactive form. Here, we investigated the mechanism of this process by using a Förster resonance energy transfer (FRET) assay that...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: van Schie, Karin A., Ooijevaar-de Heer, Pleuni, Dijk, Lisanne, Kruithof, Simone, Wolbink, Gertjan, Rispens, Theo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015024/
https://ncbi.nlm.nih.gov/pubmed/27605058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32747
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