Defective proviruses rapidly accumulate during acute HIV-1 infection

Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable levels, HIV-1 persists in CD4(+) T cells in a latent form not targeted by the immune system or ART(1–5). This latent reservoir is a major barrier to cure. Many individuals initiate ART during chronic infect...

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Udgivet i:Nat Med
Main Authors: Bruner, Katherine M., Murray, Alexandra J., Pollack, Ross A., Soliman, Mary G., Laskey, Sarah B., Capoferri, Adam A., Lai, Jun, Strain, Matthew C., Lada, Steven M., Hoh, Rebecca, Ho, Ya-Chi, Richman, Douglas D., Deeks, Steven G., Siliciano, Janet D., Siliciano, Robert F.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014606/
https://ncbi.nlm.nih.gov/pubmed/27500724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4156
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