The Sel1L-Hrd1 endoplasmic reticulum-associated degradation complex manages a key checkpoint in B cell development

Endoplasmic reticulum (ER)-associated degradation (ERAD) is a principal mechanism that targets ER-associated proteins for cytosolic proteasomal degradation. Here our data demonstrate a critical role for the Sel1L-Hrd1 complex, the most conserved branch of ERAD, in early B cell development. Loss of S...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Ji, Yewei, Kim, Hana, Yang, Liu, Sha, Haibo, Roman, Christopher A., Long, Qiaoming, Qi, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014582/
https://ncbi.nlm.nih.gov/pubmed/27568564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.003
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