A Traceless Selection: Counter-selection System That Allows Efficient Generation of Transposon and CRISPR-modified T-cell Products

Recent years have seen major breakthroughs in genome-engineering systems, such as transposon-mediated gene delivery systems and CRISPR-Cas9-mediated genome-editing tools. In these systems, transient expression of auxiliary genes is responsible for permanent genomic modification. For both systems, it...

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Bibliographic Details
Published in:Mol Ther Nucleic Acids
Main Authors: Mezzadra, Riccardo, Hollenstein, Andreas, Gomez-Eerland, Raquel, Schumacher, Ton N
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014455/
https://ncbi.nlm.nih.gov/pubmed/27003756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.13
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