Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and N-glycosylation. We show that glycogen syn...

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Publicat a:Nat Commun
Autors principals: Li, Chia-Wei, Lim, Seung-Oe, Xia, Weiya, Lee, Heng-Huan, Chan, Li-Chuan, Kuo, Chu-Wei, Khoo, Kay-Hooi, Chang, Shih-Shin, Cha, Jong-Ho, Kim, Taewan, Hsu, Jennifer L., Wu, Yun, Hsu, Jung-Mao, Yamaguchi, Hirohito, Ding, Qingqing, Wang, Yan, Yao, Jun, Lee, Cheng-Chung, Wu, Hsing-Ju, Sahin, Aysegul A., Allison, James P., Yu, Dihua, Hortobagyi, Gabriel N., Hung, Mien-Chie
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013604/
https://ncbi.nlm.nih.gov/pubmed/27572267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12632
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