aroA-Deficient Salmonella enterica Serovar Typhimurium Is More Than a Metabolically Attenuated Mutant

Recombinant attenuated Salmonella enterica serovar Typhimurium strains are believed to act as powerful live vaccine carriers that are able to elicit protection against various pathogens. Auxotrophic mutations, such as a deletion of aroA, are commonly introduced into such bacteria for attenuation wit...

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Veröffentlicht in:mBio
Hauptverfasser: Felgner, Sebastian, Frahm, Michael, Kocijancic, Dino, Rohde, Manfred, Eckweiler, Denitsa, Bielecka, Agata, Bueno, Emilio, Cava, Felipe, Abraham, Wolf-Rainer, Curtiss, Roy, Häussler, Susanne, Erhardt, Marc, Weiss, Siegfried
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013297/
https://ncbi.nlm.nih.gov/pubmed/27601574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01220-16
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