A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB with significant potency against various clinical S. aureu...

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Enregistré dans:
Détails bibliographiques
Publié dans:mBio
Auteurs principaux: Morisaki, J. Hiroshi, Smith, Peter A., Date, Shailesh V., Kajihara, Kimberly K., Truong, Chau Linda, Modrusan, Zora, Yan, Donghong, Kang, Jing, Xu, Min, Shah, Ishita M., Mintzer, Robert, Kofoed, Eric M., Cheung, Tommy K., Arnott, David, Koehler, Michael F. T., Heise, Christopher E., Brown, Eric J., Tan, Man-Wah, Hazenbos, Wouter L. W.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013292/
https://ncbi.nlm.nih.gov/pubmed/27601569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00412-16
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