A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB with significant potency against various clinical S. aureu...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Morisaki, J. Hiroshi, Smith, Peter A., Date, Shailesh V., Kajihara, Kimberly K., Truong, Chau Linda, Modrusan, Zora, Yan, Donghong, Kang, Jing, Xu, Min, Shah, Ishita M., Mintzer, Robert, Kofoed, Eric M., Cheung, Tommy K., Arnott, David, Koehler, Michael F. T., Heise, Christopher E., Brown, Eric J., Tan, Man-Wah, Hazenbos, Wouter L. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013292/
https://ncbi.nlm.nih.gov/pubmed/27601569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00412-16
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