Fluorescence-based Assay for Polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and Identification of novel antimycobacterial WecA inhibitors

Polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) is an essential enzyme for the growth of Mycobacterium tuberculosis (Mtb) and some other bacteria. Mtb WecA catalyzes the transformation from UDP-GlcNAc to decaprenyl-P-P-GlcNAc, the first membrane-anchored glycophospholipid that is responsi...

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Publicado en:Anal Biochem
Main Authors: Mitachi, Katsuhiko, Siricilla, Shajila, Yang, Dong, Kong, Ying, Skorupinska-Tudek, Karolina, Swiezewska, Ewa, Franzblau, Scott G., Kurosu, Michio
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012913/
https://ncbi.nlm.nih.gov/pubmed/27530653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2016.08.008
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