Deletion of African swine fever virus interferon inhibitors from the genome of a virulent isolate reduces virulence in domestic pigs and induces a protective response

African swine fever virus (ASFV) encodes multiple copies of MGF360 and MGF530/505 gene families. These genes have been implicated in the modulation of the type I interferon (IFN) response. We investigated the effect of modulating the IFN response on virus attenuation and induction of protective immu...

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Veröffentlicht in:Vaccine
Hauptverfasser: Reis, Ana Luisa, Abrams, Charles C., Goatley, Lynnette C., Netherton, Chris, Chapman, Dave G., Sanchez-Cordon, Pedro, Dixon, Linda K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012891/
https://ncbi.nlm.nih.gov/pubmed/27521231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.08.011
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