Cardiac action of the first G protein biased small molecule apelin agonist

Apelin peptide analogues displaying bias towards G protein signalling pathways have beneficial cardiovascular actions compared with the native peptide in humans in vivo. Our aim was to determine whether small molecule agonists could retain G protein bias. We have identified a biased small molecule,...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Read, Cai, Fitzpatrick, Christopher M., Yang, Peiran, Kuc, Rhoda E., Maguire, Janet J., Glen, Robert C., Foster, Richard E., Davenport, Anthony P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012889/
https://ncbi.nlm.nih.gov/pubmed/27475715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.07.018
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