Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer

CONTEXT: Renal cancer is a common urologic malignancy, and therapeutic options for metastatic disease are limited. Most clear cell renal cell carcinomas (ccRCC) are associated with loss of von Hippel-Lindau tumor suppressor (pVHL) function and deregulation of hypoxia pathways. OBJECTIVE: This review...

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發表在:Eur Urol
Main Authors: Schödel, Johannes, Grampp, Steffen, Maher, Eamonn R., Moch, Holger, Ratcliffe, Peter J., Russo, Paul, Mole, David R.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012644/
https://ncbi.nlm.nih.gov/pubmed/26298207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2015.08.007
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