Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis

In calcific aortic valve disease, the valve cusps undergo retraction, stiffening, and nodular calcification. The inflammatory cytokine, tumor necrosis factor (TNF)-α, contributes to valve disease progression; however, the mechanisms of its actions on cusp retraction and stiffening are unclear. We in...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Am J Pathol
Hlavní autoři: Lim, Jina, Ehsanipour, Arshia, Hsu, Jeffrey J., Lu, Jinxiu, Pedego, Taylor, Wu, Alexander, Walthers, Chris M., Demer, Linda L., Seidlits, Stephanie K., Tintut, Yin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2016
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012467/
https://ncbi.nlm.nih.gov/pubmed/27392969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.05.003
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky