Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis

In calcific aortic valve disease, the valve cusps undergo retraction, stiffening, and nodular calcification. The inflammatory cytokine, tumor necrosis factor (TNF)-α, contributes to valve disease progression; however, the mechanisms of its actions on cusp retraction and stiffening are unclear. We in...

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Bibliografiske detaljer
Udgivet i:Am J Pathol
Main Authors: Lim, Jina, Ehsanipour, Arshia, Hsu, Jeffrey J., Lu, Jinxiu, Pedego, Taylor, Wu, Alexander, Walthers, Chris M., Demer, Linda L., Seidlits, Stephanie K., Tintut, Yin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2016
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012467/
https://ncbi.nlm.nih.gov/pubmed/27392969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.05.003
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