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A Statistical Guide to the Design of Deep Mutational Scanning Experiments
The characterization of the distribution of mutational effects is a key goal in evolutionary biology. Recently developed deep-sequencing approaches allow for accurate and simultaneous estimation of the fitness effects of hundreds of engineered mutations by monitoring their relative abundance across...
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| Pubblicato in: | Genetics |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Genetics Society of America
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5012406/ https://ncbi.nlm.nih.gov/pubmed/27412710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.190462 |
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