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A Statistical Guide to the Design of Deep Mutational Scanning Experiments

The characterization of the distribution of mutational effects is a key goal in evolutionary biology. Recently developed deep-sequencing approaches allow for accurate and simultaneous estimation of the fitness effects of hundreds of engineered mutations by monitoring their relative abundance across...

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Vydáno v:Genetics
Hlavní autoři: Matuszewski, Sebastian, Hildebrandt, Marcel E., Ghenu, Ana-Hermina, Jensen, Jeffrey D., Bank, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012406/
https://ncbi.nlm.nih.gov/pubmed/27412710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.190462
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