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Developing EZH2 Targeted Therapy for Lung Cancer

Epigenetic targets are exciting new avenues for cancer drug discovery. Zhang and colleagues have designed the open-source EZH2 inhibitor JQEZ5 and shown anti-tumor efficacy in vitro and in vivo in preclinical studies in murine and human lung adenocarcinomas models expressing high levels of EZH2 (1).

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Frankel, Arthur E., Liu, Xin, Minna, John D.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012289/
https://ncbi.nlm.nih.gov/pubmed/27587466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0800
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