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Multiple LINEs of retrotransposon silencing mechanisms in the mammalian germline

Retrotransposons play an important role in genome evolution but pose acute challenges to host genome integrity, particularly in early stage germ cells where epigenetic control is relaxed to permit genome-wide reprogramming. In most species, the inability to silence retrotransposons in the germline i...

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Bibliographic Details
Published in:Semin Cell Dev Biol
Main Authors: Yang, Fang, Wang, P. Jeremy
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5011444/
https://ncbi.nlm.nih.gov/pubmed/26957474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2016.03.001
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