Sestrin2 Induced by Hypoxia Inducible Factor 1 alpha protects the Blood-Brain Barrier via Inhibiting VEGF after Severe Hypoxic-Ischemic Injury in Neonatal Rats

OBJECTIVE: Hypoxic ischemic (HI) encephalopathy remains the leading cause of perinatal brain injury resulting in long term disabilities. Stabilization of blood brain barrier (BBB) after HI is an important target, therefore, in this study we aim to determine the role of sestrin2, a stress inducible p...

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Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Shi, Xudan, Doycheva, Desislava Met, Xu, Liang, Tang, Jiping, Yan, Min, Zhang, John H
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010975/
https://ncbi.nlm.nih.gov/pubmed/27425892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.07.016
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