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A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila
Misfolding of the prion protein (PrP) is the key step in the transmission of spongiform pathologies in humans and several animals. Although PrP is highly conserved in mammals, a few changes in the sequence of endogenous PrP are proposed to confer protection to dogs, which were highly exposed to prio...
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| Publicado no: | Neurobiol Dis |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5010947/ https://ncbi.nlm.nih.gov/pubmed/27477054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.07.025 |
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