Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome

Diamond Blackfan anemia (DBA) and myelodysplastic syndrome (MDS) with isolated del(5q) are severe macrocytic anemias; although both are associated with impaired ribosome assembly, why the anemia occurs is not known. We cultured marrow cells from DBA (n = 3) and del(5q) MDS (n = 6) patients and deter...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Yang, Zhantao, Keel, Siobán B., Shimamura, Akiko, Liu, Li, Gerds, Aaron T., Li, Henry Y., Wood, Brent L., Scott, Bart L., Abkowitz, Janis L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010382/
https://ncbi.nlm.nih.gov/pubmed/27169803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf3006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados