Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome

Diamond Blackfan anemia (DBA) and myelodysplastic syndrome (MDS) with isolated del(5q) are severe macrocytic anemias; although both are associated with impaired ribosome assembly, why the anemia occurs is not known. We cultured marrow cells from DBA (n = 3) and del(5q) MDS (n = 6) patients and deter...

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Foilsithe in:Sci Transl Med
Main Authors: Yang, Zhantao, Keel, Siobán B., Shimamura, Akiko, Liu, Li, Gerds, Aaron T., Li, Henry Y., Wood, Brent L., Scott, Bart L., Abkowitz, Janis L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010382/
https://ncbi.nlm.nih.gov/pubmed/27169803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf3006
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