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A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway

Hybrid drugs are a promising strategy to address the growing problem of drug resistance, but the mechanism by which they modulate the evolution of resistance is poorly understood. Integrating high-throughput resistance measurements and genomic sequencing, we compared Escherichia coli populations evo...

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Dettagli Bibliografici
Pubblicato in:Mol Biol Evol
Autori principali: Wang, Kathy K., Stone, Laura K., Lieberman, Tami D., Shavit, Michal, Baasov, Timor, Kishony, Roy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009991/
https://ncbi.nlm.nih.gov/pubmed/26538141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msv243
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