The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain

OBJECTIVE: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms...

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Detalhes bibliográficos
Publicado no:Osteoarthritis Cartilage
Main Authors: Xu, L., Nwosu, L.N., Burston, J.J., Millns, P.J., Sagar, D.R., Mapp, P.I., Meesawatsom, P., Li, L., Bennett, A.J., Walsh, D.A., Chapman, V.
Formato: Artigo
Idioma:Inglês
Publicado em: W.B. Saunders For The Osteoarthritis Research Society 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009895/
https://ncbi.nlm.nih.gov/pubmed/27208420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2016.05.015
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