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The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain
OBJECTIVE: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms...
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| 發表在: | Osteoarthritis Cartilage |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
W.B. Saunders For The Osteoarthritis Research Society
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5009895/ https://ncbi.nlm.nih.gov/pubmed/27208420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2016.05.015 |
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