The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain

OBJECTIVE: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Osteoarthritis Cartilage
Egile Nagusiak: Xu, L., Nwosu, L.N., Burston, J.J., Millns, P.J., Sagar, D.R., Mapp, P.I., Meesawatsom, P., Li, L., Bennett, A.J., Walsh, D.A., Chapman, V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: W.B. Saunders For The Osteoarthritis Research Society 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009895/
https://ncbi.nlm.nih.gov/pubmed/27208420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2016.05.015
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