Activation of the Yeast UBI4 Polyubiquitin Gene by Zap1 Transcription Factor via an Intragenic Promoter Is Critical for Zinc-deficient Growth

Stability of many proteins requires zinc. Zinc deficiency disrupts their folding, and the ubiquitin-proteasome system may help manage this stress. In Saccharomyces cerevisiae, UBI4 encodes five tandem ubiquitin monomers and is essential for growth in zinc-deficient conditions. Although UBI4 is only...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: MacDiarmid, Colin W., Taggart, Janet, Jeong, Jeeyon, Kerdsomboon, Kittikhun, Eide, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009263/
https://ncbi.nlm.nih.gov/pubmed/27432887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.743120
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